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pentobarbital will decrease the level or result of lumefantrine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Coadministration with sturdy CYP3A4 inducers may end up in diminished serum concentrations and lack of antimalarial efficacypentobarbital will lessen the extent or result of avanafil by affecting hepatic/intesti